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Somatic Cell Genome Editing (SCGE) Outreach

@somaticediting

The Somatic Cell Genome Editing Consortium is funded by the @NIH_CommonFund. Retweets ≠ endorsements. Visit the SCGE Platform scge.mcw.edu/platform/
scge.mcw.edu Joined September 2019
456 Following 967 Followers 3K Posts

Latest posts 5

Somatic Cell Genome Editing (SCGE) Outreach @somaticediting
Here, researchers' findings establish AAV-vectorized cytokines as a durable, locally delivered immuno-gene therapy platform for high-grade gliomas.

cell.com/molecular-ther…
www.cell.com AAV immuno-gene therapy platform delivering vectorized cytokines defines a new modality for... AAV-vectorized interferon-β converts immunologically cold high-grade glioma into an immune-reactive tumor microenvironment. Local cytokine expression induces tumor apoptosis, microenvironment...
Somatic Cell Genome Editing (SCGE) Outreach @somaticediting
Here, researchers are developing a 14.3 kDa anti-CD8 VHH tracer (B), along with a nonbinding control tracer (C), in order to track CD8+ (“cytotoxic”) T cells in malignant tumors during immunotherapy by Positron Emission Tomography (PET).

pmc.ncbi.nlm.nih.gov/articles/PMC13…
pmc.ncbi.nlm.nih.gov Tracer Kinetic Modeling of a 14 kDa Anti-CD8 PET Tracer (2C8v144) for In Vivo Estimation of CD8... We are developing a 14.3 kDa anti-CD8 VHH tracer, [18F]-2C8v144 (binding tracer, B), along with a nonbinding control tracer, [18F]-2C8v145 (C), in order to track CD8+ (“cytotoxic”) T cells in...
Somatic Cell Genome Editing (SCGE) Outreach @somaticediting
ICYMI - New FDA Guidance Document: Individualized Human Genome Editing Products: Considerations for BLA Submission and Postapproval Management

fda.gov/regulatory-inf…
www.fda.gov Individualized Human Genome Editing Products This is the draft guidance for industry, Individualized Human Genome Editing Products: Considerations for BLA Submission and Postapproval Management
Somatic Cell Genome Editing (SCGE) Outreach @somaticediting
We're back with another SCGE Spotlight! This month, we've got:
- 2 recent publications
- Links to our "Meet the Expert" webinar series recordings
- Upcoming SCGE researcher presentations at ASGCT Breakthroughs

linkedin.com/pulse/scge-spo…
www.linkedin.com SCGE Spotlight #7 In this edition of the SCGE Spotlight, we’ve got two recent publications, our “Meet the Expert” webinar series, and upcoming presentations by consortium researchers. Let’s get started.