Guru P. Sonpavde, MD

New #bladdercancer #clinicaltrial opening now: Bladder-preservation for muscle-invasive #bladdercancer (MIBC) - #TroFuse055 is a Phase III clinical trial that evaluates the value of neoadjuvant sacituzumab tirumotecan (Sac-TMT) + MK3475A followed by consolidation MK3475A when combined with conventional chemoradiotherapy - this trial builds upon the value that chemoradiation brings to patients with MIBC who have elected to avoid radical cystectomy surgery - 1) Sac-TMT is a Trop2 binding antibody drug conjugate (ADC) conjugated to a potent topoisomerase-1 inhibitor payload (belotecan) and 2) MK3475A is subcutaneous pembrolizumab - Trial is opening globally and sponsored by @Merck - we are pleased to offer at our institution @AdventHealthCFL Cancer Institute Orlando, #Florida - Please note @BladderCancerUS @FLASCO_ORG @tompowles1 @DrYukselUrun @drenriquegrande @AndreaNecchi @shilpaonc - clinicaltrials.gov/study/NCT07829…

#clinicaltrial commentary - is a Phase 1 trial for #cancer therapy a good option? My opinion from @AdventHealthCFL - please note @VivekSubbiah @BladderCancerUS @FLASCO_ORG @VuMedi @OncoAlert @OncBrothers @oncodaily

We are #Hiring at @AdventHealthCFL #cancer Institute, Orlando, #Florida area! Looking for Genitourinary (GU) #cancer-focused medical Hematologist-Oncologist to also support the rapidly growing Phase I solid tumor #clinicaltrial program- especially suitable for a junior medical oncologist who is interested in a hybrid of #prostatecancer focused medical oncology practice + clinical trials (#research) and wants to develop an #earlydrugdevelopment career- and an opportunity to collaborate with world class urology and Radiation Oncology team - flexibly tailor the practice to fit career goals - @AdventHealthCFL was ranked as one of the top 20 hospitals by US News & World Report in 2025-and the among the top 50 in the nation for 6 medical specialties including #Cancer - we are the largest healthcare system in central Florida - and a teaching program with Internal Medicine residency - and will have a Hematology-Oncology fellowship in the near future
adventhealthfloridaphysicianjobs.com/Physician_Job/…

#PenileCancer update at #MaTOSGU2026 - Pleased to attend and discuss from @Adventhealth #Cancer Institute @AdventHealthCFL, Orlando, #Florida - Global collaboration is critically important to accelerate advances #GSRGT (Global Society of Rare GU Tumors) @AndreaNecchi @SpiessPhilippe @JadChahoud @apolo_andrea - thanks to organizers @PGrivasMDPhD @LuisERaez1 @mecmededucation

Pleased to have mentored @rohitjainMD on this #clinicaltrial combining EV plus pan -FGFR inhibiting targeted agent Erdafitinib for advanced #bladdercancer #urothelialcarcinoma