Stuart Buck

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@stuartbuck1

Executive Director, goodscienceproject.org
Formerly: @arnold_ventures, @harvard_law, @kellogghansen
Classical guitarist and author

Georgia newsletter.goodscienceproject.org Joined June 2011

664 Following 7.9K Followers 25K Posts

Latest posts 5

Stuart Buck @stuartbuck1 2d

Funny how everyone who is optimistic about AI "curing disease" in the next 10 years either 1) has zero training in biology/medicine, or else 2) works for an AI company selling its book.

Ash Jogalekar Verified account @curiouswavefn 2d

This recent story about the high profile failure of two promising heart disease drugs is a great example of the kind of work that AI has cut out for itself to do.

Even at the end of the trials, the doctors and scientists who did it are wondering if they picked the wrong mechanism, the wrong trial or the wrong patient population. This was in spite of the best data that they had which was suggestive of the intervention.

Drug discovery remains incredibly hard because biology is so ill-understood. AI can certainly contribute insights and speed up parts of the process, but the idea that it can somehow magically prevent these kinds of failures is akin to a religious belief.

nytimes.com/2026/11/07/sci…
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Stuart Buck @stuartbuck1 4d

"AI is going to solve all biology and human disease"!

Meanwhile, we don't even have enough data about basic human anatomy, let alone about things like cellular vaults.

Fox News Health Verified account @foxnewshealth 4d

Two 19-year-old Tulane University sophomores discovered a previously unknown muscle attachment deep in the human hip during a routine cadaver lab session — a find so unusual that even their professor, a co-editor-in-chief of Gray's Anatomy, couldn't identify it.

Dominic Roy and Cooper Bruce had been assigned to measure the fusion point between two well-known hip muscles when Roy spotted something unfamiliar on the other side of the iliac fascia.

After an exhaustive search through medical literature and textbooks turned up nothing, the team confirmed it was a new anatomical discovery. The findings were recently published in the journal Clinical Anatomy.

Full story here foxnews.com/health/college…

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Stuart Buck @stuartbuck1 Nov 1

Once I was delayed for 8 hours in the middle of winter at O'Hare in Chicago. When we were finally boarding, a pilot deadheading was right in front of me. I asked him what he knew about the delay, and he said that conditions at altitude had been really icy.

I asked what that would mean, and he said, "If the plane ices up, then it would just nosedive into the earth."

I said, "You know, I don't mind the 8-hour delay so much any more."

LapseR8 Verified account @lapseR8wx Nov 1

Per transcript and telemetry, aircraft encountered extreme high altitude icing conditions with heavy precip at 47 degrees below zero. It essentially became a rock with engines and nosedived nearly 40,000 feet in a minute or two. Just a terrible situation, this is why meteorology is so critical in aviation
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Stuart Buck @stuartbuck1 Nov 1

Can't believe this 1969 doc was using AI (look at all the em-dashes):

Stuart Buck @stuartbuck1 Oct 28

An idea: maybe it makes sense for a major federal science funding agency to be led by someone with a track record of picking top talent across multiple fields.

Jim O’Neill Verified account @regardthefrost Oct 28

Exceptional talent is widely distributed. Permission to use it is not.

We started the Thiel Fellowship to find extraordinary young people and give them the freedom to pursue ambitious ideas.

Fifteen years later, see what they’ve built.
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