Chrysothemis Brown

@themis_brown

Physician Scientist @MSKCancerCenter | Freeman Hrabowski Scholar @HHMINEWS | Pediatrician | Immunologist @chrysothemisbrown.bsky.social

New York thebrownlaboratory.com Joined September 2013

808 Following 1.9K Followers 698 Posts

Latest posts 5

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Chrysothemis Brown @themis_brown Feb 3

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. nature.com/articles/s4158…
Beautiful work led by exceptional @HHMI Gilliam fellow @YoselinAPI and @MSK postdoc Tyler Park 🧵 1/

www.nature.com Ontogeny and transcriptional regulation of Thetis cells Nature - A study of antigen-presenting cells called Thetis cells sheds light on their development and transcriptional regulation in mice, which has implications for the tolerance of gut microbiota...

Chrysothemis Brown @themis_brown Nov 5

Thank you for highlighting our work and for the thoughtful review and helpful suggestions! We're working on it!

Bhavya Singh @bhavyasighs Nov 4

Thrilled to share a mini digest I wrote with the @preprintclub @neoviral highlighting an exciting new preprint from @themis_brown @YuriPritykin. You can access the preprint here - biorxiv.org/content/10.648…
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Chrysothemis Brown @themis_brown Jun 20

Congrats to Ichiro Taniuchi's lab! Happy to have been part of this study with @YoselinAPI showing that Runx–CBFβ complexes are essential for the development of tolerogenic Thetis cells. Overexpression of Runx enhances TC IV and pTreg differentiation.
nature.com/articles/s4159…

www.nature.com Runx–CBFβ regulates the development of tolerogenic Thetis cells Nature Immunology - Taniuchi and Brown and colleagues report that the Runx–CBFβ transcription factor complex plays a crucial role in the development of intestinal RORγt+...

Chrysothemis Brown @themis_brown Mar 12

We are hiring! The Brown Lab is looking for a computational biologist to join our team.
If you enjoy working with single-cell and spatial genomics data and want to study how immune cells develop and function, we’d love to hear from you!

Apply here:
hhmi.wd1.myworkdayjobs.com/External/job/M…

Chrysothemis Brown @themis_brown Oct 17, 2025

Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal tolerance and immunity @NatImmunol rdcu.be/eLtB1 nature.com/articles/s4159…