Thomas Norman

@thenormanlab

Associate Member in csBio at Memorial Sloan Kettering. Perturb-seq, single-cell functional genomics, and techniques for perturbing the genome.

New York, NY thenormanlab.com Joined July 2024

232 Following 1.3K Followers 135 Posts

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Thomas Norman @thenormanlab Oct 13

1/ Most genes and variants matter somewhere but look silent in any one cell model. Can we build conditions that reveal phenotypes? With @kanishkadey, we engineer cell states to expose hidden disease biology and trace how genetic risk reaches disease genes. biorxiv.org/content/10.648…

Visual abstract: activating TFs singly and in pairs engineers new cell states, and the Mosaic model learns how TFs combine. Findings: hidden AMD risk variants, state-dependent convergence, and chromatin priming.

Thomas Norman @thenormanlab Feb 4

My lab at MSKCC in New York is hiring for two positions. Join us at the frontier of functional genomics, studying fibroblast state transitions, combinatorial genetics, and ECM in disease. Please share with anyone who might be a good fit! (Mustache not required.)

Thomas Norman @thenormanlab Jan 20

New preprint on technologies to scale up CRISPR screens.

We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells.

We also introduce an approach for cloning lentiviral libraries with billions of elements.

Thomas Norman @thenormanlab Aug 6, 2025

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Thomas Norman @thenormanlab Dec 17, 2024

Our Multiome Perturb-seq paper is now out in @CellSystemsCP! As discussed in my thread on the preprint, this is an approach for linking CRISPR-mediated genetic perturbations to their effects on cellular chromatin state and gene expression. x.com/thenormanlab/s…

Thomas Norman @thenormanlab Jul 29, 2024

Excited to share our preprint "Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome & epigenome". This work extends single-cell CRISPR screens to simultaneously profile gene expression & chromatin accessibility.

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