Billy Treacy

@treacy_billy

PhD chemist at Innocular AI - He/him
UCLA Chemistry & Biochemistry
Former (& forever) Tar Heel

Los Angeles, CA Joined June 2019

68 Following 77 Followers 72 Posts

Latest posts 5

Billy Treacy @treacy_billy Oct 17, 2025

Check out the last major work from my time at UCLA! We developed a misuse deterrent peptide-based oxycodone prodrug for the treatment of acute pain. This is yet another testament to the work that federally funded research can enable! @uclachem
pubs.acs.org/doi/10.1021/ja…

pubs.acs.org An Orally Administered Misuse Deterrent Opioid Prodrug for Treatment of Acute Pain Abstract. Opioids are a powerful class of medicines due to their ability to alleviate acute pain. However, the use of prescription opioids has led to an ep

Billy Treacy @treacy_billy Feb 4, 2025

Over the last few years, we've figured out how to change the rates of elementary steps in Au(I)/Au(III) redox reactions, specifically oxidative addition, ligand exchange, and reductive elimination, by modifying the steric and electronic properties of the ligand and substrate! 1/3

Billy Treacy @treacy_billy Dec 9, 2024

The finalized version of this work is now online at @JOC_OL - congrats to all the authors especially @elaineychao!
pubs.acs.org/doi/10.1021/ac…

pubs.acs.org Electronic Effects of Bidentate P,N‑Ligands on the Elementary Steps of Au(I)/Au(III) Reactions... Abstract. Oxidant-free Au(I)/Au(III)-catalyzed cross-coupling has been recently enabled by the use of bidentate P,N-ligands. To further develop these P,N

Billy Treacy @treacy_billy Sep 26, 2024

Super excited to share the spotlight with Elaine on this one and highlight some of the exceptional work that she did as an undergrad!
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Billy Treacy @treacy_billy Sep 26, 2024

Here's something that @elaineychao and I (and some others) worked on the past few years! We detail how the electronic properties of P,N ligands affect the rates of elementary organometallic steps in Au(I)/Au(III) reactions. @HeatherDMaynard @organomimetic
chemrxiv.org/engage/chemrxi…

chemrxiv.org Electronic Effects of Bidentate P,N-Ligands on the Elementary Steps of Au(I)/Au(III) Reactions... Oxidant-free Au(I)/Au(III) catalyzed cross-coupling has been recently enabled by the use of bidentate P,N-ligands. To further develop these P,N-ligands, computational studies were performed to...

Billy Treacy @treacy_billy Sep 10, 2024

Happy to see our latest pursuit in Au(III)-mediated S-arylation out as a preprint now! We demonstrate the utility of computational screening of P,N-ligands for S-arylation, resulting in some very rapid reactions!
@organomimetic @HeatherDMaynard
chemrxiv.org/engage/chemrxi…