Thomas Weimbs, PhD

@weimbslab

Biomedical research lab at the University of California Santa Barbara focusing on polycystic kidney disease and other things!

Santa Barbara, California, USA labs.mcdb.ucsb.edu/weimbs/thomas/ Joined November 2016

769 Following 1.7K Followers 998 Posts

Latest posts 5

Thomas Weimbs, PhD @weimbslab Aug 31

1/3 Is tolvaptan's kidney "benefit" in ADPKD a measurement artifact?
New paper: high water intake → less eating → muscle loss → lower creatinine → falsely "preserved" eGFR. ~1%/yr muscle change could explain the TEMPO3:4 effect.
Cystatin C measured but never reported. Why?

Thomas Weimbs, PhD @weimbslab Aug 15

Another nail in the coffin of the “protein consumption causes kidney disease” myth

Generations of people were told to lower protein consumption, without evidence, which can cause adverse effects.
Study here:
academic.oup.com/ckj/article/19…

academic.oup.com Higher habitual protein intake is not linked to decline of iohexol-measured GFR in adults ≥40 years ABSTRACTBackground. High habitual dietary protein intake may increase glomerular workload and contribute to hyperfiltration, but the long-term renal effect

Thomas Weimbs, PhD @weimbslab Aug 10

Very large study and long-term suggests that ketogenic metabolic therapy is effective in slowing or preventing chronic kidney disease progression

virtahealth.com/press/virta-he…

www.virtahealth.com Virta Health Dramatically Reduces Risk of Advanced Kidney Disease by 62% in Landmark, Real-World... Peer-reviewed findings challenge longstanding assumptions about nutrition and kidney health, suggesting metabolic care may play a far greater role.

Thomas Weimbs, PhD @weimbslab Aug 9

New study supports kidney protection by ketosis:
--> 1392 patients with type 2 diabetes
--> median 23.2-month follow-up
--> highest ketone body tertile was associated with significantly lower risk of ≥40% eGFR decline

sciencedirect.com/science/articl…

Thomas Weimbs, PhD @weimbslab Aug 7

We evolved to produce BHB — a ketone that signals to the kidneys like a hormone.

But modern diets keep insulin high and ketone production switched off. The result: a chronic, near-universal "BHB deficiency."

New review doi.org/10.1152/ajpend…
#Ketosis #KidneyHealth #ADPKD