Craig Wilen

@WilenLab

Physician-scientist. Dad. Husband. Associate Professor @yaleibio @yale_labmed. We study host-viral interactions #covid #norovirus @wilenlab.bsky.social

New Haven, CT wilenlab.com Joined May 2011

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Craig Wilen @WilenLab 6d

Excited to share our new preprint identifying endothelial protein C receptor (EPCR) as a receptor for Langya virus. Langya was identified in 2022 in patients with acute febrile illness and linked to shrews biorxiv.org/content/10.648… @YaleMed @YaleIBIO @NIH

Craig Wilen @WilenLab Sep 25

Very cool and important paper on bat evolution and genomics. nature.com/articles/s4158…

www.nature.com Reference genomes and fossils revise bat family phylogeny and biogeography Nature - An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

Craig Wilen @WilenLab Sep 16

nature.com/articles/s4156…

www.nature.com Aminopeptidase N is a receptor for hedgehog merbecoviruses Nature Microbiology - Hedgehog merbecoviruses utilize hedgehog aminopeptidase N, but not the human orthologue, as their entry receptor. Structural resolution of the glycoprotein–receptor...

Craig Wilen @WilenLab Aug 19

When chemistry meets virology. Excited to share this great work led by Tanja Hahn and wonderful collaboration with the Pyle lab. RNA structures regulate norovirus life cycle and enable rational attenuation in vivo. @YaleMed @YaleIBIO @CellCellPress sciencedirect.com/science/articl…

Craig Wilen @WilenLab Jun 24

Excited to share our paper just out: IgA is necessary and sufficient to prevent norovirus infection in mice | Science Translational Medicine science.org/doi/10.1126/sc…

www.science.org IgA is necessary and sufficient to prevent norovirus infection in mice Mucosal IgA prevents norovirus infection in a murine model, which informs vaccine design and therapeutic strategies.