Gene Yeo’s Lab at UC San Diego

Your genetic risk variant may have been harmless for 60 years. Then the aging RNA machinery stops buffering it.
New review in Trends in Cell Biology by our grad student @sgrandles : RNA dysregulation belongs alongside DNA damage & proteostasis as a driver of neuronal vulnerability. sciencedirect.com/science/articl…

New in @NatureSMB 🧬 We screened 730 RNA-binding proteins and found 281 that control circular RNAs, from how they’re made to how much protein they produce. Thanks to our collaborators at MSK, Columbia, and UCSD, and to my amazing lab, led by Tao Yu nature.com/articles/s4159…

New in @NatStructMolBio! 🧬 We screened 730 RNA-binding proteins and found 281 that control circular RNAs, from how they’re made to how much protein they produce. Thanks to our collaborators at MSK, Columbia, and UCSD, and to my amazing lab, led by Tao Yu nature.com/articles/s4159…

Where does a coronavirus hold its own genome?
We mapped it — in live infected cells — for three of SARS-CoV-2’s key proteins. Several grip sites turned out to be control switches for viral copying and protein production. Block the grip, slow the virus. New antiviral targets. Congrats @jsxianglab, @sandra_leibel et al and for @UCSD for seeding our project. today.ucsd.edu/story/rna-prot…

Our new paper: we found that in in vitro stem cell models, ARID5A, an RNA-binding protein in brain immune cells (microglia), links immune signaling, waste clearance, and iron metabolism — and controlling it may protect neurons in neurodegeneration. nature.com/articles/s4146…