BryanRoth

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@zenbrainest

James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'

Here, now. pdsp.unc.edu/rothlab/public… Joined November 2013

599 Following 18K Followers 31K Posts

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BryanRoth @zenbrainest Aug 6

A suite of engineered mice for interrogating psychedelic drug actions
#psychedelics
Congrats to Yi-ting, Ariel, Bill, Gavin, Dewran, Pierre and too many others to mention. A yuuge effort and we hope that folks will find these mice useful
nature.com/articles/s4159…

www.nature.com A suite of engineered mice for interrogating psychedelic drug actions Nature Neuroscience - Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across...

BryanRoth @zenbrainest 14h

Novel gene therapy lets drug dampen brain cell activity, reducing seizures | Science | AAAS science.org/content/articl…

www.science.org Novel gene therapy lets drug dampen brain cell activity, reducing seizures In first clinical result using “chemogenetic” strategy, a team in China treated three patients to control epilepsy

BryanRoth @zenbrainest 18h

The power of model organisms!

Jun-Liszt Li @poppingjun 19h

@zenbrainest Thanks! I think this work marks another milestone, paying tribute to your pioneering engineering of the DREADD system in yeast back in 2007! pnas.org/doi/10.1073/pn…
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BryanRoth @zenbrainest 20h

Early morning view. Vacation day 3

BryanRoth @zenbrainest 1d

Amen to that but…hats off to them for actually doing it in what appears to be excellent fashion.

Prof. Michael Lin @MichaelLinLab 1d

Awesome, but it's such a shame that US VCs are too busy putting $250B into data centers so we can have AI slop, when just 1/10000th of that, a rounding error, would have allowed a trial like this in the US.

And the funding system assures we can never do this within a university
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