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Andrew Smith

@AJsmith231

Staff Scientist in the @Pagliarini_lab at @WUSTLmed, St. Louis. Big mitochondria fan! Views my own | 🇮🇪 | he/him
St Louis, MO Joined October 2015
76 Following 76 Followers 72 Posts

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Andrew Smith @AJsmith231
~90% of mitochondrial proteins have at least one phosphosite.
Only ~1% of these sites have a reported function.

Is this regulation or noise?

We silenced 10 resident mitochondrial phosphatases, one at a time, to find out. New preprint 🧵👇
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Andrew Smith @AJsmith231
Excited to finally share this story!

Preprint thread here: x.com/AJsmith231/sta…
Pagliarini Lab @Pagliarini_Lab Sep 29
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @AJsmith231, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology.
biorxiv.org/content/10.648…
# Mitochondria
#HHMINews
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Andrew Smith @AJsmith231
It looks like phosphorylation in mitochondria is a pretty important regulatory mechanism 👀
Pagliarini Lab @Pagliarini_Lab Oct 13, 2023
I’m pleased to share our new work on the mitochondrial phosphatase PPTC7 led by @nieminm! Check out the important roles this protein plays in mitophagy and metabolic regulation.

#mitochondria
nature.com/articles/s4146…
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Andrew Smith @AJsmith231
I may actually be able to see my family for the first time in almost two years!
The US Traveller @SammualM Sep 20, 2021
‼️BREAKING‼️ “Vaccinated passengers will be able to travel to the US from the EU and UK from November onwards, the Biden administration will announce on Monday, in a major diplomatic victory for Brussels and London”. [Financial Times] ft.com/content/ed63ac… #LoveIsNotTourism
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