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Pagliarini Lab

@Pagliarini_Lab

Mitochondrial systems biochemistry
HHMI/WashU School of Medicine pagliarinilab.org Joined March 2015
236 Following 3.2K Followers 219 Posts

Latest posts 5

Pagliarini Lab @Pagliarini_Lab
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @AJsmith231, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology.
biorxiv.org/content/10.648…
# Mitochondria
#HHMINews
www.biorxiv.org Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture Phosphorylation is a pervasive mitochondrial protein post-translational modification, yet the extent of its influence over mitochondrial functions remains unclear. To identify dynamic mitochondrial...
0 replies 9 reposts 32 likes 2.1K views View on X
Pagliarini Lab @Pagliarini_Lab
PI is a prominent #mitochondrial lipid but little is known about its regulation and function. In work led by @Zak_Bakes and Rachel Guerra, we discovered that Fmp30p is a PI hydrolase that affects IM protein organization and CoQ production.
#HHMInews
#WashU
nature.com/articles/s4146…
www.nature.com Fmp30p is a mitochondrial phosphatidylinositol hydrolase that modulates CoQ biosynthesis Nature Communications - The mechanisms contributing to organellar membrane lipid composition remain unclear. Here, Baker and Guerra et al. characterize the mitochondrial protein Fmp30p as a...
1 replies 14 reposts 29 likes 2.7K views View on X
Pagliarini Lab @Pagliarini_Lab
I'm excited to share our new manuscript led by @PatrickForny now online at medRxiv. We integrated >26M molecular measurements to discover multiple new mitochondrial protein regulatory functions. Interactive website coming soon!
#Mitochondria
#HHMI
medrxiv.org/content/10.648…
www.medrxiv.org Cooperative Architecture of Mitochondrial Proteome Homeostasis Mitochondria are semi-autonomous organelles whose generation and maintenance demand precise expression, processing, and assembly of >1,000 proteins encoded across two genomes. To explore this...
2 replies 18 reposts 54 likes 5.5K views View on X
Pagliarini Lab @Pagliarini_Lab
Attention undergraduates: 10 days left to apply for the new @hhmi_science Cech Fellows program — a nine-week summer research experience that provides rising juniors and seniors with a $15K stipend, or $12K plus housing for those placed at Janelia.
#HHMI
hhmi.org/programs/cech-…
www.hhmi.org Summer Undergraduate Research Experience (REU) | Cech Fellows | HHMI The Cech Fellows Program is a paid, nine-week summer research experience for rising college juniors and seniors designed to empower the next generation of scientific leaders through mentorship,...