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Dr. Andrew Koutnik | Metabolism Scientist

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@AKoutnik

🔬 PhD Scientist | Metabolism & Human Performance
🧬 Co-founder: Pursuit Protein
🏅 Elite Diabetes & Human Performance Consultant
andrewkoutnik.com Joined December 2011
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Dr. Andrew Koutnik | Metabolism Scientist Verified account @AKoutnik
🚨Our Landmark Sport Nutrition Analysis in Endocrine Reviews — spanning 100+ years & ~600 studies🔬— challenges the foundations of the sports nutrition industry & guidelines, exposing potential harm to athletes' health.
This is the most comprehensive pub on nutrition's impact on performance (5+ years in the making). What we found is critical to athletes, coaches, dieticians, and the scientists who write guidelines with FREE study link below:

1) 🍞"Carb-loading" is misguided?
Current sport nutrition guidelines (i.e., @ACSMNews, @IntSocietySN, @Gatorade Sport Science Institute) recommend 5–12 g/kg CHO/day and 60–90 g CHO/hour. What does that mean?

📈This can push some athletes to over 1000 carbohydrates/day. Multiple meta-analyses in the report revealed that sport nutrition guidelines have over-emphasized muscle glycogen and carbohydrate oxidation levels...yet these metrics didn't consistently align with performance... so what metric predicts performance?
See #2. 👇

2)🧠Primary performance driver? Sustaining total brain energy (glucose + ketones + lactate)—not muscle glycogen or carb oxidation.
In >160 sports performance studies, 88% showed that carb intake only benefits performance when blood glucose plummeted in the placebo group, triggering early fatigue in non-carb athletes due to brain energy deficit. Carbs maintained blood glucose and brain energy, and this out-predicted every other metric. Yet, the brain's role has been sidelined in sports nutrition, ignoring evidence since the 1920s of its pivotal impact on performance.

3)🔥High carbohydrate intake paradoxically accelerates glycogen breakdown and suppresses fat oxidation during exercise.
This contradicts many of the sports nutrition marketing claims promoting high levels of carbohydrate supplementation (60-120g/hour) to "spare" muscle glycogen AND evidence showing that higher fat oxidation correlates with better performance.

4)🫀Health risks of sports nutrition guidelines? Emergent evidence has demonstrated that high-carbohydrate intake can lead to prediabetes in a percentage of athletes. This analysis also reveals that current sport nutrition guidelines' carbohydrate intake levels create a metabolic environment during exercise analogous to diabetes:
-⬆️circulating insulin
-⬇️fat oxidation
-⬆️glycogen breakdown
-🔒forced reliance on glucose as fuel

This is critical. We show that athletes ARE NOT immune to the metabolic problems driven by the food environment.

5)🥵Ketogenic athletes CAN "bonk" too...but not if they fuel correctly.
Contrary to claims, athletes on ketogenic diets can and do bonk—like on high-carb diets—due to dropping blood glucose. The lack of strategic carbohydrate placement was a mistake many keto-athletes made when trying to reach their peak performance. Small targeted brain-fuel supplements (10g/hour) during exercise boost peak performance without high-carb loads.

After 4-week adaptation, ketogenic performance equals high-carb performance...but BOTH high and low-carb athletes benefit from ~10g/hour carbs to maintain glucose/brain energy for exercise >60 minutes in duration, improving performance 22%. It will be interesting to see how other brain fuels can also assist (ketones and lactate).

🔗FREE Study Link: doi.org/10.1210/endrev…

📣CONCLUSIONS: This landmark analysis challenges over half a century of scientific assumptions in sports nutrition—and explains how they became embedded in official guidelines—with implications reaching beyond elite athletes to public health and chronic disease prevention.

Please share this widely with athletes, coaches, dietitians, and scientists to help optimize not just peak performance, but lifelong health. 🤝
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Dr. Andrew Koutnik | Metabolism Scientist Verified account @AKoutnik
Can't even hate on this. Good for you @bryan_johnson
Bryan Johnson Verified account @bryan_johnson 2d
To dunk, I need to put 585 lb of force into the floor within 0.2 seconds.

This squat gets me 97% of the way there on strength.

I'm working on explosiveness. I'm still on the ground too long when jumping.

Side note: this is the most I've ever squatted.
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Dr. Andrew Koutnik | Metabolism Scientist Verified account @AKoutnik
There are many people saying "this is impossible and dangerous."

#1) This CAN and HAS occured in T1D, if new onset, and more often in adults since slowing progressing (LADA). Now 4+ case series and reports confirming this in new onset cases with T1D after going low carb.

#2) There is immunologic and metabolic rationale. C-peptide has been shown to be restored as well in some case following low carb, despite C-peptide previously being low enough for T1D diagnosis.

#3) The preliminary evidence and mechanistic rationale for low carb and T1D honeymoon remission was good enough that we successfully wrote an NIH R01 to study it in children with T1D (it was awarded; active and ongoing: clinicaltrials.gov/study/NCT05899…)
Dr Shawn Baker 🥩 Verified account @SBakerMD 3d
Type 1 diabetic (new onset) goes carnivore, insulin requirements go to zero
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