BCH Innovation News

Today, the FDA approved the first CRISPR therapy to treat #sicklecell disease, developed at Boston Children's! Read how Drs. Stu Orkin, @bloodgenes, & @danielevanbauer found they could activate life-sustaining hemoglobin proteins in sickle cell patients. ms.spr.ly/6017irPT9

A pilot study suggests that up to half of cases of ADHD could be diagnosed genetically. Interestingly, many of the genes affected are also involved in other neurodevelopmental disorders, though the variants in ADHD were milder. 👇 ms.spr.ly/6019iREoP

In an analysis of >5M cell images, skin cells with very high OCT4 levels were successfully reprogrammed into iPSCs, find Thorsten Schlager et al. But exposing cells to those levels was not sufficient to ensure reprogramming success. @BCHStemCell 👉 ms.spr.ly/6017iMRtB

Dr. Stu Orkin chatted with @NatRevDrugDisc about how his team's discovery of BCL11A paved the way for a CRISPR therapy for haemoglobinopathies, like sickle cell disease. Learn more 👇 @DFBC_PedCare
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Why are we mentally sharper at certain times of day? In @ScienceAdvances, the @Lipton_Lab spells out how circadian rhythms interact with the brain, showing that a clock protein, BMAL1, shows up at synapses at particular times of day. 👇 ms.spr.ly/6012izdsr