New paper out in @ScienceAdvances
TOP2B activity is locally inhibited during the estrogen response to favour the accumulation of DNA supercoiling and regulatory chromatin contacts that trigger transcriptional induction
science.org/doi/10.1126/sc…
TOP2B activity is locally inhibited during the estrogen response to favour the accumulation of DNA supercoiling and regulatory chromatin contacts that trigger transcriptional induction
science.org/doi/10.1126/sc…
www.science.org TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction During the estrogen response, TOP2B activity controls DNA supercoiling to shape chromatin contacts and regulate gene induction. 
