Evan Weber

@EvanWeberPhD

Assistant Professor @PennMedicine @ChildrensPhila | CAR T, cancer immunotherapy, T cell fitness | evanweberphd.bsky.social

Philadelphia, PA theweberlab.org Joined June 2018

658 Following 3.3K Followers 1.6K Posts

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Evan Weber @EvanWeberPhD Apr 10, 2024

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen. 1/

nature.com/articles/s4158…

www.nature.com FOXO1 is a master regulator of memory programming in CAR T cells Nature - The transcription factor FOXO1 has a key role in human T cell memory, and manipulating FOXO1 expression could provide a way to enhance CAR T cell therapies by increasing CAR T cell...

Evan Weber @EvanWeberPhD Aug 25

Could not be more proud @rob_hapke for his masterful thesis defense! Co-mentoring Rob with @andyjminn has been an absolute joy, and today was a good reminder of how important and gratifying mentorship is.

Congrats Dr. Hapke, this is just the beginning!

Evan Weber @EvanWeberPhD Jun 4

Another example showing that repurposing cancer-targeting CAR T can do wonders for patients afflicted by other B cell-mediated diseases

nature Verified account @Nature Jun 3

A single dose of engineered immune cells has helped two men and one woman to receive life-saving kidney transplants. Their bodies would normally reject donated organs.

go.nature.com/4fZ8uoG
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Evan Weber @EvanWeberPhD May 23

**THESE** data suggest

Evan Weber @EvanWeberPhD May 1

The manufacturing step for CAR T has always been ripe for innovation.

Here, Gattinoni and Kochenderfer groups show that pharmacologic enrichment of memory-like Tscm cells boosts CD19 CAR T expansion and durable persistence in patients, even at low doses!

cell.com/cell/fulltext/…

www.cell.com Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse Donor-derived CD8⁺ CAR TSCM cells exhibit enhanced expansion and a favorable safety profile, inducing complete responses at low doses without lymphodepletion. Their distinctive in vivo behavior and...