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Andy Minn

@andyjminn

At MSK, dedicated to improving cancer immunotherapy. Pondering resistance mechanisms, chronic inflammation, unexpected roles of interferon. Views my own.
New York, NY minnlab.org Joined July 2017
326 Following 1.6K Followers 525 Posts

Latest posts 5

Andy Minn @andyjminn
Congrats @NancyZh60672287 and @KSusztak for this amazing work showing a path toward more effective and insightful single cell diagnosis and discovery from patient samples!
Nancy Zhang @NancyZh60672287 Aug 7, 2025
Hey we are in the post-atlasing era — time for single cell research to translate into the clinic! How? Try CellSpectra. See this thread by the amazing @KSusztak:
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Andy Minn @andyjminn
Congrats, Chris and team! A really fascinating auto regulatory circuit. A great example of how unraveling the complexities of unexpected modulatory pathways could be the key to better immunotherapies.
Klebanoff_Lab @KlebanoffLab Jul 22, 2025
🚨Today, in @NatureCancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy @MSKCancerCenter @parkerici @MSK_DeptOfMed
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Andy Minn @andyjminn
Congrats Aaron and team! The biological implications and the translational insight uncovered is fascinating. Discovery that some patients might naturally synthesize biologics that may improve immunotherapy, including blocking antibodies to type I IFN? Wow 🤯
Aaron Ring Verified account @aaronmring Jul 23, 2025
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too?

That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below

nature.com/articles/s4158…
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Andy Minn @andyjminn
This study describes one of the most amazing IFN-stimulated genes (ISGs) I have ever learned about!! Congrats @megclarks, Jorge Henao Mejia, and team! Your work is amazing. Thanks also to @TheMarkFdn for supporting this project as part of the Mark Foundation Center at Penn.
meg clark @megclarks Jul 1, 2025
Thrilled to share our paper on how mitochondrial complex IV remodeling can modulate TAM functions and promote anti-tumor immunity! with @ksimeono, @MFMich1, @Notorious_MHC, @rakez_krish, @delafuentelab, @andyjminn, @JHMLab and those not on X! Out now in @ImmunityCP 🎉
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