EvolutionaryScale

biohub.org Launching the first large-scale scientific initiative combining frontier AI with frontier biology... The large-scale scientific effort combines frontier AI with frontier biology to accelerate discovery and solve disease.

Alex Rives Verified account @alexrives · Nov 6, 2025

Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub.

This is the first large scale scientific effort to combine frontier AI and frontier biology.

I feel an incredible sense of optimism in this moment. There is a path to build predictive models of life that can fundamentally accelerate science, and unlock a new understanding of disease.

biohub.org/blog/frontier-…

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The Align Foundation Verified account @Align_Bio · Jul 8, 2025

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🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️

#AIforBiology #ClimateTech #ProteinEngineering #OpenScience

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Alex Rives Verified account @alexrives · Jan 16, 2025

We're thrilled to present ESM3 in @ScienceMagazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence.

Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering.

ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins.

ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein.

We estimate this is equivalent to simulating five hundred million years of evolution.

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The Nobel Prize Verified account @NobelPrize · Oct 9, 2024

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

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