During our investigation of protein pyrophosphorylation, we identified a novel post-translational modification (PTM), which we have termed 'Protein Oligophosphorylation'.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Fiedlerlab
@FiedlerLab
Twitter account of the Fiedler group. (student handled)
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Follow up to our discovery of endogenous protein pyrophosphorylation, Arif Celik, a PhD student from our lab, decided to select one of the newly found „pyrophosohoproteins“ and see what effect does this PTM have on protein activity.
pubs.acs.org/doi/10.1021/ja…
pubs.acs.org/doi/10.1021/ja…
pubs.acs.org An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of N‑Acetylgluco... Abstract. While the function of protein phosphorylation in eukaryotic cell signaling is well established, the role of a closely related modification, prote Happy to share our latest paper on protein pyrophosphorylation - yes, it exists! It has been a long journey with many wonderful co-workers and collaborators. Thank you all!
@JeremyAMMorgan @MRuwolt
nature.com/articles/s4158…
@JeremyAMMorgan @MRuwolt
nature.com/articles/s4158…
www.nature.com Extensive protein pyrophosphorylation revealed in human cell lines Nature Chemical Biology - A tailored proteomics workflow to identify endogenous protein pyrophosphorylation in human cells was developed, revealing the dependence of the modification on inositol... After a lot of efforts from our former post doc Sarah Hostachy, we are do happy to see this out!
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs (Dorothea Fiedler and co-workers) @FiedlerLab @LeibnizFMP onlinelibrary.wiley.com/doi/10.1002/ch…View quoted post on X
Unexpected results often lead to fascinating discoveries!
Have a look at this new paper from our lab where @timaguirre_chem developed an inhibitor for IP6Ks and found out some really cool mechanistic details about the inhibition
elifesciences.org/articles/88982
Have a look at this new paper from our lab where @timaguirre_chem developed an inhibitor for IP6Ks and found out some really cool mechanistic details about the inhibition
elifesciences.org/articles/88982
elifesciences.org An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric... A subtle mutation in the ATP-binding site of inositol hexakisphosphate kinases increases their conformational flexibility and thereby makes them susceptible to isozyme-selective, allosteric inhibit...