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Ignasi Toledano

@IgnasiToledano

Collaborative PhD with @BenLehner and @GenomeDataLab; playing around with tons of mutations, RNA and translation
Barcelona Joined July 2022
449 Following 150 Followers 52 Posts

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Ignasi Toledano @IgnasiToledano
A much improved version of this, today out in @NatureGenet ! with @BenLehner and @FranSupek nature.com/articles/s4158…
Ignasi Toledano @IgnasiToledano Aug 9, 2023
Time to share my PhD work where we quantified the translational readthrough of thousands of pathogenic stop codons and trained predictive models to predict drug-induced readthrough of any stop codon. With the priceless guidance from @FranSupek +@BenLehner! biorxiv.org/content/10.110…
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Ignasi Toledano @IgnasiToledano
Time to share my PhD work where we quantified the translational readthrough of thousands of pathogenic stop codons and trained predictive models to predict drug-induced readthrough of any stop codon. With the priceless guidance from @FranSupek +@BenLehner! biorxiv.org/content/10.110…
www.biorxiv.org Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules Premature termination codons (PTCs) cause ∼10-20% of Mendelian diseases and are the major mechanism of tumor suppressor gene inactivation in cancer. A general strategy to alleviate the effects of...
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