Colin Jackson

biorxiv.org/content/10.6... most proteins are multi domain but our understanding of how architectures evolve is limited - we mapped 40K chitinases and show a stepwise grammar of domain gain/loss and localisation changes that predicts ecological strategy and physiological function

Super cool paper

Love this

biorxiv.org/content/10.110… Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory

Ok we have a paper on biorxiv that we have updated and improved. BUT now it is a “different” paper. What is best practice? Do we upload as a revision of the previous one? Can we change the title or does that mess up indexing etc… old one already been cited a few times.