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This is a thread on our paper by Eric Fagerberg .
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
science.org/doi/10.1126/sc…
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
science.org/doi/10.1126/sc…
www.science.org KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress... An interesting target, but we think it will be insufficient without other factors like Tbet and Zeb2. Experiments are ongoing to test these ideas.View quoted post on X
Lastly I want to thank a few people who helped in the process. @sarah_h_ross who handled our paper and especially our collaborators
