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Shingo Kajimura Lab
@KajimuraLab
Lab at Beth Israel Deaconess Medical Center, Harvard Medical School, HHMI studying bioenergetics. #Metabolism #Mitochondria #Adipocytes @HarvardMed @HHMINEWS
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An excellent review of our recent paper on mitochondrial control of fuel switching – thank you!! The bottleneck of fat burning | Science science.org/doi/10.1126/sc…
www.science.org The bottleneck of fat burning A mitochondrial transport protein promotes carnitine synthesis in mice when fat consumption is needed Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use? Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/sc…
www.science.org Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosyn... I am honored to write this award lecture article as a single author, but it reflects the collective effort of our fellows, students, and collaborators. Thank you all for being part of this journey! Lecture video available diabetesjournals.org/diabetes/artic…
diabetesjournals.org An Unexpected Journey Into Brown Fat Research for Metabolic Health: The 2025 Outstanding Scientific... For many years, brown adipose tissue (BAT) was primarily regarded as a “heat organ” for rodents. Over the past 15 years, however, research in this field ha Super interesting ! A new UCP1-independent thermogenic mechanism in peroxisomes sciencedirect.com/science/articl…