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Shingo Kajimura Lab @KajimuraLab
Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use?  Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/sc…
www.science.org Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosyn...
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Shingo Kajimura Lab @KajimuraLab

Replying to @KajimuraLab

To our surprise, the carnitine biosynthesis pathway influences the optimal efficacy of GLP1-based anti-obesity therapies! You can see the full MS here until it lasts: science.org/eprint/ARC749J….
www.science.org Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosyn...
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Liz @bicyclizt

Replying to @KajimuraLab

@KajimuraLab You note the role of Thyroid hormone. Carnitine supplementation has been shown to help with fatigue among some people (with sufficient T3) with continuing symptoms despite treated hypothyroidism. pubmed.ncbi.nlm.nih.gov/27432821/ Are there implications for this population?
pubmed.ncbi.nlm.nih.gov L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on... Hypothyroid patients experience fatigue-related symptoms despite adequate thyroid hormone replacement. Thyroid hormone plays an essential role in carnitine-dependent fatty acid import and oxidation....