Klebanoff_Lab

@KlebanoffLab

A translational research lab @MSKCancerCenter focused on the immunobiology and therapeutic potential of genetically engineered #Tcells and #TCRs. Est.2016 @NYC.

New York City, New York mskcc.org/research-areas… Joined April 2021

2.3K Following 3.3K Followers 679 Posts

Latest posts 5

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Klebanoff_Lab @KlebanoffLab Oct 27, 2023

🚨🧬💉Everything you wanted to know about TCR therapies* (*but were afraid to ask). Check out our new review in @NatRevDrugDisc 👇. A wonderful collaboration between @KlebanoffLab, @ND_BakerLab, @QuezadaLab, and @ToniRibas12. @MSKCancerCenter @parkerici rdcu.be/dpCtp

Klebanoff_Lab @KlebanoffLab Oct 31

🎃To all the clincial stage cell therapy investigators out there - Happy Halloween! 🧬 🥼🎃 #Tcellpower

Klebanoff_Lab @KlebanoffLab Oct 27

🚨New collaborative paper with @KathyHsuLab. We show that NKG2C+CD8+ TKLR cells can be TCR/CAR-engineered to deliver potent antitumor activity with ⬆️persistence, ⬇️ exhaustion, and ⬇️CRS potential. @MSKCancerCenter @MSK_DeptOfMed @parkerici @JCI_org jci.org/articles/view/…

Klebanoff_Lab @KlebanoffLab Oct 25

👉Another important reminder that immunogenicity can be uncoupled from clinical benefit. #MRNA's adjuvant pancreatic cancer vaccine data: 100% of patients developed T cell responses against >/=1 vaccine-encoded predicted neoantigens *yet* 45% developed short term relapse.

https://irp.cdn-website.com/89dd0539/files/uploaded/mRNA-4157-P101+Poster_ESMO+2026_Final.pdf

Klebanoff_Lab @KlebanoffLab Sep 16

A @parkerici enabled reunion of NCI Surgery Branch alumni. Remarkable physician-scientists, friends, and mentors. #Tcellpower! @PatrickHwuMD @CSHinrichsMD @nrestifo