Knight Genetics

@KnightGenetics

Official account of Prof. Julian Knight's lab at @NDMOxford @OxfordMedSci and @HumanGeneticsOx

Using functional genomics to understand the human immune system

Oxford, England well.ox.ac.uk/research/resea… Joined February 2016

351 Following 563 Followers 257 Posts

Latest posts 5

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Knight Genetics @KnightGenetics Mar 3, 2022

Some of the big questions raised by the COVID-19 pandemic are 'Why do we all have such a different reaction to the infection? From the mild cases to the seriously sick?'

Our #COMBAT paper in @CellCellPress aims to explore these questions

A 🧵by Dr Justin Whalley & @DrCarlaCohen

Knight Genetics @KnightGenetics Mar 2

Our new study shows a genetic variant fine-tunes MTOR and immune crosstalk, improving survival in pneumonia-associated #sepsis - toward personalised treatments.
Congrats to @pingzhangneho and everyone involved! @HumanGeneticsOx @CAMS_COI_Ox @NatureComms
nature.com/articles/s4146…

www.nature.com Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in... Nature Communications - Sepsis is a heterogeneous inflammatory disease and it is believed treatment requires suitable stratification based on the underlying disease pathology and immunology. Here...

Knight Genetics @KnightGenetics Apr 27, 2023

Our research on the chromatin landscape of ankylosing spondylitis (AS) has just been published in @CellGenomics. An important step towards future drug discovery.

Congratulations to @DrCarlaCohen, @HumanGeneticsOx, and and everyone involved!

Carla Cohen @DrCarlaCohen Apr 27, 2023

Really excited to present our research on epigenomics of #AnkylosingSpondylitis, a spinal arthritis.

Published this week in @CellGenomics: doi.org/10.1016/j.xgen…

1st authors: Andrew Brown, Ola Mielczarek, Gabriele Migliorini and @DrCarlaCohen

A 🧵

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Knight Genetics @KnightGenetics Apr 26, 2023

We are excited to share our recent work mapping the host response to sepsis at single-cell resolution. The study, led by @andrewjkwok and published in @NatImmunol, identifies a subset of immature neutrophils which is increased in severe sepsis.

Big thanks to everyone involved!

Nature Immunology @NatImmunol Apr 24, 2023

Julian Knight and colleagues find that altered granulopoiesis and increases in immature immunosuppressive neutrophil subsets are associated with poor outcomes in some patients with sepsis. Read it here: rdcu.be/daDeU

nature.com/articles/s4159…
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Knight Genetics @KnightGenetics Nov 3, 2022

We are excited to share our new study, out now in @ScienceTM!

We developed a machine learning framework (SepstratifieR) to stratify infection patients by risk of severe illness.

SepstratifieR is publicly available and applicable to sepsis, influenza and COVID-19.

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