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Luis de la Torre-Ubieta

@LTULab

We study human cortical development and neuropsychiatric disease. BSCRC member: stemcell.ucla.edu/member-directo…
delatorre-ubietalab.dgsom.ucla.edu Joined January 2018
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Luis de la Torre-Ubieta @LTULab
New study from our lab led by @ckvuong and A Weber where we uncover mechanisms of Down syndrome during development. Thanks to all co-authors and the labs of @jsteinlab, W Lowry, D Geschwind, and @mikejg84 for their invaluable contributions.

science.org/doi/10.1126/sc…
www.science.org A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated... Down syndrome (DS) is the most common genetic cause of intellectual disability, yet the cellular and molecular mechanisms driving this developmental disorder remain unclear. In this study, we...
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Luis de la Torre-Ubieta @LTULab
New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome.
#brain #singlecell #multiomics #DownSyndrome

biorxiv.org/content/10.110…
www.biorxiv.org A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated... Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this...
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Luis de la Torre-Ubieta @LTULab
Very proud of this incredible team which led this innovative work to move us closer to understanding the impact of isoform diversity in the developing brain and neuropsychiatric disorders.
Ashok Patowary, PhD @ashokpatowary May 23, 2024
Its out today in @ScienceMagazine.
science.org/doi/10.1126/sc…
Special thanks to @connorjops for his prompt analytical support during the project, and @ckvuong for her meticulous review ensuring no oversights in the manuscript.
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