HalicLab

@LabHalic

Dept. of Structural Biology, St. Jude Children's Research Hospital
@StJudeStructBio

Memphis, USA stjude.org/directory/h/ma… Joined August 2019

266 Following 704 Followers 124 Posts

Latest posts 5

HalicLab @LabHalic Dec 19, 2025

Improved the nucleosome in cryo-ET dataset EMPIAR-11830 (@AbhayKot) to 4.2 Å resolution, with bulky side chains now visible. #CryoET #TEAMTOMO

HalicLab @LabHalic Sep 12, 2025

We analyzed cryo-ET dataset EMPIAR-11830 (@AbhayKot) and achieved in situ nucleosome reconstruction at 6.7 Å resolution, revealing clear DNA and histone density. Many more cryo-ET findings from @LabHalic are on the way. #CryoET #TEAMTOMO.

HalicLab @LabHalic Apr 3, 2025

Our recent publication in Cell Research visualizes continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H.
nature.com/articles/s4142…

www.nature.com Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H Cell Research - Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H

HalicLab @LabHalic Mar 11, 2025

In our latest work we visualize continuous motion of nucleosomal DNA by human chromatin remodeler SNF2H.
biorxiv.org/content/10.110…

www.biorxiv.org Mechanisms of chromatin remodeling by an Snf2-type ATPase Chromatin remodeling enzymes play a crucial role in the organization of chromatin, enabling both stability and plasticity of genome regulation. These enzymes use a Snf2-type ATPase motor to move...

HalicLab @LabHalic Nov 21, 2024

Thrilled to share our first lamellae made here at St. Jude! Great work by Martin, Silvija and Robert!