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Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
biorxiv.org/content/10.110โฆ
www.biorxiv.org FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors Cells selectively remove damaged or excessive mitochondria through mitophagy, a specialized form of autophagy, to maintain mitochondrial quality and quantity. Mitophagy is induced in response to... biorxiv.org/content/10.110โฆ