Shixian Lin

Excited to share our review on sense codon reassignment in JZUS-B! From proteome-wide stochastic labeling to precision site-specific engineering, we highlight how competitive codon recoding (including our RCR strategy) expands the chemical space of proteins and enables next-generation molecular tools. rdcu.be/GdXdwZ9ck1Pa

Excited to share our ALPHA platform in Vita. A rationally designed alanine suppressor tRNA that enables durable, disease-agnostic PTC readthrough across diverse protein classes and inheritance modes. AAV9 delivery rescued phenotypes in MPS I, DMD, Alport, and FAP models. vita-journal.com/vita/EN/10.153…
#tRNA #GeneticCode #RareDisease #NonsenseSuppression

Thrilled to share our review paper on @TrendsBiochem. We summarize the latest breakthroughs in expanding the genetic code beyond single noncanonical amino acids (ncAAs) — from orthogonal translation systems and quadruplet codons to rare codon recoding — enabling the synthesis of sophisticated “new-to-nature” biopolymers with multiple distinct functionalities.
authors.elsevier.com/a/1m%7E-z3S6Gf…

Deeply grateful to Nicholas Polizzi for insightful expert opinion and Stacey Paiva for enthusiastic guidance. We're excited to share the full inspiring story behind the paper and the eureka moment in the Research Briefing! @NatureChemistry nature.com/articles/s4155…

Excited to share our new paper in @NatureChemistry!

Building on our Rare Codon Recoding (RCR) work @ScienceMagazine, we developed a multi-rare-codon strategy enabling the simultaneous incorporation of up to 5 distinct ncAAs in mammalian cells!

nature.com/articles/s4155…