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Cells make toxic metabolites every minute they’re alive. How do they survive them?
In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
science.org/doi/10.1126/sc…
In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
science.org/doi/10.1126/sc…
www.science.org NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formald... Cancer cells must balance detoxification of reactive metabolic by-products while preserving redox homeostasis, but how this trade-off is managed remains unclear. The Kelch-like ECH-associated protein... 
