Vascular malformations, particularly when associated with disfigurement, are worth sequencing, for both diagnostic refinement and the search for actionable alterations.
pubmed.ncbi.nlm.nih.gov/41544971/
pubmed.ncbi.nlm.nih.gov/41544971/
Modern Pathology
@ModernPathology
Official Journal of @TheUSCAP, focused on clinical and translational research in #pathology of #humandisease. Sibling Journal: @LIjournal.
270 Following 14K Followers 1.5K Posts
Latest posts 5
Primary perianal adenocarcinoma with pagetoid intra-epithelial extension - these look a bit like HPV-associated lesions, lack HPV transcripts, and have TP53, ERBB2, and MYC abnormalities, without typical rectal adenocarcinoma mutations (APC, KRAS, BRAF). pubmed.ncbi.nlm.nih.gov/41106477/
Just a bread and butter case: with better control of HIV disease it is easy to forget about Kaposi sarcoma - this example with hyaline globules. (erythrophagolysosomes).
This is a subcutaneous pleomorphic liposarcoma. It looks like a "generic" high-grade pleomorphic sarcoma until the pleomorphic lipoblasts are spotted. They may be in a spectrum with the more recently described myxoid pleomorphic liposarcoma.
pubmed.ncbi.nlm.nih.gov/34168281/
pubmed.ncbi.nlm.nih.gov/34168281/
It's a vintage article from Modern Pathology, but keratin expression in schwannomas is an "always" pitfall! IYKYK!
pubmed.ncbi.nlm.nih.gov/16357842/
pubmed.ncbi.nlm.nih.gov/16357842/
