Twitxy
Saved
@NilssonLabCph's profile picture
View on X

Jakob Nilsson

@NilssonLabCph

Cell biologist working in Copenhagen. Opinions are my own
Joined September 2017
236 Following 1K Followers 1.4K Posts

Latest posts 5

Jakob Nilsson @NilssonLabCph
Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. nature.com/articles/s4159…
www.nature.com A proteome-wide dependency map of protein interaction motifs Nature Structural & Molecular Biology - Ambjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using...
2 replies 7 reposts 26 likes 1.5K views View on X
Jakob Nilsson @NilssonLabCph
Looking forward to a great line up of speakers at #CRISPRMED26 in Copenhagen: linkedin.com/pulse/crisprme…
Come join us for some excellent science in the heart of Copenhagen - still places available
www.linkedin.com CRISPRMED26 - The World of CRISPR Medicine Meets Again in Copenhagen, April 2026 The 3rd CRISPR MEDiCiNE Conference – April 14–16, 2026, Copenhagen Key Dates for CRISPRMED26: December 8th 2025: Early bird registration deadline January 12th 2026: Abstract submission deadline...
Jakob Nilsson @NilssonLabCph
Our paper on PP2A-B55 substrate recognition out now. Great collaboration with @FurmanLab @torbenheick @KettenbachLab @jp_arulanandam. We integrate AlphaFold modelling and protein design with biochemical and cell based assays
science.org/doi/10.1126/sc…
www.science.org Substrate recognition principles for the PP2A-B55 protein phosphatase α helices in PP2A-B55 substrates bind a conserved pocket on B55 through a common mechanism that is conserved in eukaryotes.
2 replies 10 reposts 39 likes 2.6K views View on X
Jakob Nilsson @NilssonLabCph
Base editing screen targeting all feasible S/T/Y residues (close to 600.000) to investigate phospho-dependent signaling.
biorxiv.org/content/10.110…
www.biorxiv.org Massively parallel interrogation of human functional variants modulating cancer immunosurveillance Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized clinical cancer treatment, while abnormal PD-L1 or HLA-I expression in patients can significantly impact the therapeutic...