Picotti Lab

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech !

Read here👉: doi.org/10.1038/s41587…

🔬 Highlights:

- Uses an experimental library of peptide markers integrated with a structural proteomics workflow.

- Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy.

- Supports the structural modelling of protein complexes and the design of compounds targeting them

Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab

@ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery

We are proud to announce that Ruedi Aebersold, founder of our institute and beloved colleague, will be awarded the Dr H.P. Heineken Prize for Biochemistry & Biophysics 2024. He receives it together with @labs_mann for their groundbreaking contributions to proteomics @ETH_en

Our paper describing a method to screen for conformation-specific protein-protein interactions is out @MolSystBiol.

Read it here: doi.org/10.1038/s44320…

The approach can also be used to map interaction sites.

@IMSB_ETH @ETH @ETH_en
#proteomics #massspectrometry #interactomes

Congratulations, Albert. An exciting research area you are pioneering. We look forward to exciting discoveries ahead.

High resolution protein complex analysis beyond AP-MS by the Gstaiger group: nature.com/articles/s4159….

Nice collaborative adventure at @IMSB_ETH from the @MGstaigerlab members @FabianFrommelt , @anfossati , @federico_uliana and from @bwollsch lab members