Manfredini Lab

@RM_Lab_

Prof. Rossella Manfredini's Lab @ UNIMORE. Myeloproliferative Neoplasms | single-cell | mouse models | immunophenotyping | AIRC Mynerva group

Modena, Emilia Romagna Joined March 2023

128 Following 43 Followers 61 Posts

Latest posts 5

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Manfredini Lab @RM_Lab_ Aug 30, 2024

1/Excited to share our latest study on the effect of chromosome 9p duplication in JAK2-mutated Myeloproliferative Neoplasms - now out in
@LeukemiaJnl 🎉
nature.com/articles/s4137…
🧵below:

www.nature.com Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T-cell exhaustion in... Leukemia - Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T-cell exhaustion in JAK2-mutant myeloproliferative neoplasms

Manfredini Lab @RM_Lab_ Apr 26

We're now at the end of a fantastic #ESHMPN2026 meeting full of fruitful discussions! So grateful to have had the opportunity to present our data on combined MEK+JAK inhibition to target MF and single-cell multiomic analysis to dissect JAKi resistance in MF!
@ESHaematology

Manfredini Lab @RM_Lab_ Sep 2, 2024

If you're in coffee break, get a glimpse of our discoveries at Behind the Paper go.nature.com/4fzaO34
Congrats to all the authors who teamed up in this project! 📄🙋🏻‍♂️🙋🏻‍♀️🙋🏻

communities.springernature.com Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T-cell exhaustion in...

Manfredini Lab @RM_Lab_ Jul 3, 2024

Congrats @LaraTavernari , @RuggieroNorfo , and @SebastianoRontauroli for leading this fantastic study on exhausted cytotoxic T cells rescue in #myelofibrosis xenografts! Out today, read it in @AjHematology 👉 doi.org/10.1002/ajh.27…

onlinelibrary.wiley.com Targeting exhausted cytotoxic T cells through CTLA‐4 inhibition promotes elimination of neoplastic... Anti-CTLA-4 monoclonal antibody treatment dramatically decreased monocytes and granulocytes numbers in the BM of PDX mice.

Manfredini Lab @RM_Lab_ Apr 27, 2024

Great poster session at #ESHMPN2024. Come see our work about chromosome 9p duplication in JAK2V617F MPN patients 🧬