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Rossjohn lab

@RossjohnLab

Led by Prof @Jamie_Rossjohn FRS we are focused on understanding molecular bases underpinning protective and aberrant immunity
Monash University, Australia rossjohnlab.com Joined July 2014
666 Following 1.5K Followers 4.7K Posts

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Rossjohn lab @RossjohnLab
In collaboration with labs
@PN0rmski @KatherineKedz @AndrewB34372462 @syctong and co-authors, paper published
@MonashUni:
An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania: Cell cell.com/cell/fulltext/…
www.cell.com An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First... Predominant genetic variants found in First Nations peoples of the Oceania region influence the function of natural killer cells and may explain population-specific susceptibility to diseases,...
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Rossjohn lab @RossjohnLab
Congrats to PhD student, Liam Rashleigh, whose 1st authored paper on gd T cell receptor recognition was published today @Structure_CP
cell.com/structure/full…
#GDTcellclub @MonashUni @RossjohnLab
www.cell.com Antibody-like recognition of a γδ T cell receptor toward a foreign antigen Rashleigh et al. utilized phycoerythrin, a bacterial derived protein, to explore immune reactivity of B cells, αβ T cells, and γδ T cells. All lymphocytes directly recognized PE, while T cell...
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Rossjohn lab @RossjohnLab
In collaboration with @NicoleLaGruta1 and colleagues, latest paper from @Jamie_Rossjohn lab describing role of Lck-coreceptor assocation in T cell function. @MonashUni
science.org/doi/10.1126/sc…
www.science.org LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR... LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
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Rossjohn lab @RossjohnLab
Latest paper from lab, where Awad et al describe how cigarette smoke impacts that MAIT-MR1 axis and implications for lung diseases. In collaboration with Fairlie, Hansbro and Corbett labs doi.org/10.1084/jem.20…
@MonashBDI @nhmrc @WaelAwadMoh @MonashUni @Jamie_Rossjohn @JExpMed
rupress.org Cigarette smoke components modulate the MR1–MAIT axis Cigarette smoke is a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mech