Sidhant Chopra

@SidChop

Neuroscientist and psychologist interested in better treatments, brains & psychosis. Research Fellow @UniMelb @orygen_aus

Melbourne, Victoria github.com/sidchop Joined September 2016

1.1K Following 1.5K Followers 2.3K Posts

Latest posts 5

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Sidhant Chopra @SidChop Jun 29

🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠

nature.com/articles/s4138…

Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4

www.nature.com Widespread synaptic density loss in schizophrenia follows molecular and network architecture Molecular Psychiatry - Widespread synaptic density loss in schizophrenia follows molecular and network architecture

Sidhant Chopra @SidChop Sep 3

🧠 Excited to share the results of our placebo-controlled RCT in psychosis: cortical thinning in the first year of illness is very likely not because of antipsychotic medication, but due to the illness itself. Made possible by @AFornito, @PatMcGorry ++ biologicalpsychiatryjournal.com/article/S0006-…

www.biologicalpsychiatryjournal.com Differential Effects of Illness and Antipsychotics on Cortical Thinning in First-Episode Psychosis:... Cortical gray matter loss is a common finding in magnetic resonance imaging (MRI) studies of psychosis and can progress with ongoing illness. A major unresolved question concerns whether these...

Orygen @orygen_aus Sep 3

RESEARCH | Led by Dr @SidChop, this world-first study has answered a controversial and long debated question about the brain changes seen in psychosis.

Details: bit.ly/4h5EuaO

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Sidhant Chopra @SidChop Aug 19

Delighted to play a small role in is amazing study from @adeelrazi and a brilliant team. Psychedelics align brain activity with the environmental context. 👇🏾👇🏾 Check out the thread for links to the open data 👇🏾👇🏾

Adeel Razi @adeelrazi Aug 19

Our new paper in @Nature is now out.

Psychedelics don’t simply disorder the brain. Using fMRI, EEG and AI in 62 psychedelic-naive adults, we found hidden, context-sensitive organisation beneath the apparent chaos -- strongest in people reporting more positive, profound experiences and a reduced sense of separation from the world.

The paper: nature.com/articles/s4158…

Huge congratulations to @dpsyc42 who led from the front, @novelli_leo and @MKhajehnejad were exceptional in performing highly sophisticated and complex data analyses and thanks the whole @ConnectPsi team and collaborators.

Our explainer: theconversation.com/new-research-s…

Data descriptor: nature.com/articles/s4159…

ML model (TAVRNN): nature.com/articles/s4200…

Fully open-access dataset: openneuro.org/datasets/ds006…

Code for processing and cleaning data: github.com/razilab/psicon…

@matthewdgreaves Tmarin Barta, @ManaBiabani, @SidChop, @anilkseth, @RCarhartHarris, @FredBarrettPhD, @KatrinPreller, @gary_egan

@turnerinstitute @MonashPsych, @Monash_FMNHS, @MonashUni @CIFAR_News

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Sidhant Chopra @SidChop Jul 17, 2025

V useful paper by @bttyeo @Leon_Oo1 & @csabaorban out in @Nature. Scan for longer if you want to predict behaviour using fMRI and save $. Check out their calculator: thomasyeolab.github.io/OptimalScanTim….
Also another great use of our TCP data set (pmc.ncbi.nlm.nih.gov/articles/PMC11…).

Thomas Yeo @bttyeo Jul 17, 2025

1/11 Excited to share our @Naturestudy led by @Leon_Oo1 @csabaorban @ZShaoshi

doi.org/10.1038/s41586…

It is well-known that AI performance scales with logarithm of sample size (Kaplan, McCandlish 2020), but in many domains, sample size can be # participants or # measurements...

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Sidhant Chopra @SidChop Jun 17, 2025

Check out our latest open data release 👇🏾👇🏾👇🏾

Download dataset: openneuro.org/datasets/ds005…
Data paper: nature.com/articles/s4159…

Justin Baker @JustinBakerMD Jun 6, 2025

🚨Thrilled to share the Transdiagnostic Connectome Project, a new open dataset in Scientific Data! @HolmesLab_BHI @bttyeo @SidChop
🧠 fMRI + >50 behavioral measures
📊 241 participants across psychiatric diagnoses

🔗 nature.com/articles/s4159…

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