The Colonna Lab

@TheColonnaLab

We study innate immunity with a focus on ILCs, macrophages, and DCs. The account is led by trainees. @wusm_pathology @WUSTLmed

St. Louis, MO sites.wustl.edu/colonnalab Joined April 2021

118 Following 4K Followers 105 Posts

Latest posts 5

The Colonna Lab @TheColonnaLab Aug 15

New paper from the Colonna lab! cMAF is a key regulator of BAM identity and drives communication with brain arteries via IGF1. We show that this cMAF-dependent program in BAMs supports cerebrovascular function in mice and is protective against AD.

cell.com/cell/fulltext/…

www.cell.com Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript... This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

The Colonna Lab @TheColonnaLab Apr 29

What defines human pDC diversity? Our newest work led by @UlezkoAlina in @ImmunityCP uncovers a complex landscape shaped by age and tissue niche, including a cycling pDC subset that declines with age but persists in the BM & expands in malignant BPDCN. shorturl.at/99Zui

www.cell.com Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset... Ulezko Antonova et al. examine plasmacytoid dendritic cells (pDCs) in lymphoid tissues from infancy to adulthood and identify a cycling population of pDCs in fetal and infant lymphoid organs that is...

The Colonna Lab @TheColonnaLab Apr 29

Excited to share our latest work in J Exp Med! We identify LINGO4 as a key regulator of ILC3 fitness, IL-22 production and microbiota homeostasis, with major impact on host defense against enteric infection. Check it out!

doi.org/10.1084/jem.20…

rupress.org LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis Fachi et al. identify LINGO4 as a key regulator of ILC3s, coordinating mitochondrial fitness and IL-22 production. LINGO4 deficiency disrupts ILC3 function

The Colonna Lab @TheColonnaLab Mar 6

Our study is out in @ScienceMagazine! It shows that CAR-expressing astrocytes (CAR-A) can recognize and clear amyloid aggregates, reducing pathology and restoring microglial homeostasis in AD models.
Led by Yun Chen, Alex Liu and @khainotkaiorky!

doi.org/10.1126/scienc…

www.science.org Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy Alzheimer’s disease (AD) is the leading cause of dementia and is characterized by progressive amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti-amyloid...

The Colonna Lab @TheColonnaLab Feb 28

Excited to share our new work in @SciImmunology, led by @zefachi! Mesenchymal cells produce PDGF-D during colitis, driving species-specific ILC3 programs: via PDGFRβ in mice (IL-22, repair) and NKp44 in humans (type I response, pathogen clearance).

science.org/eprint/EFDJ3BJ…

www.science.org Divergent ILC3 responses to PDGF-D control mucosal immunity PDGF-D engages PDGFRβ in mice and NKp44 in humans to drive ILC3 responses.