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Griffin Lab

@The_GriffinLab

Structural biology lab @Bio21Institute @UniMelb led by Mike Griffin.
Victoria, Australia Joined February 2019
78 Following 247 Followers 80 Posts

Latest posts 5

Griffin Lab @The_GriffinLab
Great fun to work with @NatalieASims reflecting on new insights from the Garbers lab doi.org/10.1111/febs.1…, and open questions still to be answered surrounding craniosynostosis-associated variants in the IL-11 signalling machinery!
febs.onlinelibrary.wiley.com/doi/10.1111/fe…
Prof Natalie A Sims @NatalieASims Feb 8, 2024
Interleukin 11 (IL-11) receptor complex mutations are associated with craniosynostosis, but how does it happen? @The_GriffinLab and I had fun writing this editorial for @FEBSJournal based on new work from the Garbers lab - so much more to learn! febs.onlinelibrary.wiley.com/doi/10.1111/fe…
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Griffin Lab @The_GriffinLab
Great to see this beautiful work published today. And wonderful to be part of the global team advancing this amazing program!
nature.com/articles/s4146…
Leann Tilley @LeannTilley Jan 31, 2024
#Malaria parasites are specifically targeted by a new class of reaction-hijacking inhibitors. Targeting a tRNA charging enzyme, #OpenSourceMalaria compound causes parasites to self-destruct. An amazing collaborative effort from multiple sites across the globe. #Drugs #Parasites.
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Griffin Lab @The_GriffinLab
Really proud of this work published today understanding the assembly of the IL-11 signalling complex, dynamics of the gp130 receptor subunit, and how to inhibit IL-11 signalling. A brilliant collaboration! @riley_dm, @big_french_man, @PutoczkiLab.
doi.org/10.1038/s41467…
www.nature.com Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory... Nature Communications - Interleukin (IL-)11 is a signaling protein that plays key roles in several human diseases. Here the authors describe structures of IL-11 in complex with its receptors and...
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