ToposBio

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@ToposBio

Redefining druggable space with AI-driven protein modeling.

San Francisco Joined December 2024

19 Following 540 Followers 17 Posts

Latest posts 5

ToposBio @ToposBio Oct 23

Understanding protein dynamics can open new paths to treating difficult diseases.

We spoke with GamesBeat about Topos-2, Topos-Bind, and our approach to designing drugs for dynamic proteins.

Thanks @deantak for the conversation!

gamesbeat.com/topos-bio-is-u…

gamesbeat.com Topos Bio is using AI to create treatments for "undruggable" diseases | interview Topos Bio, an AI-powered biotechnology company, has introduced two new AI foundation models that could help predict how new proteins can be used to treat previously "undruggable" diseases.

ToposBio @ToposBio Oct 23

Missed us on MTS? Here’s a clip from our conversation about modeling dynamic proteins and designing drugs for challenging disease targets.

Thanks @MTSlive for having us!

MTS @MTSlive Oct 21

Topos Bio CEO Ryan Zarcone explains why designing drugs for Parkinson's and Alzheimer's is almost impossible for humans, but a perfect problem for AI:

"When a chemist designs a drug for a protein, the model is static. I have this protein, it has a shape, and I’m trying to fill that shape with a drug."

"These really dynamic proteins, like those involved in Parkinson’s and Alzheimer’s, don’t have one shape. They have potentially thousands of different shapes that they’re constantly interconverting between, kind of like someone who’s dancing."

"That becomes basically impossible when you tell a human, design something for these thousand things at the same time. It’s really only been possible to start doing that with AI."
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ToposBio @ToposBio Oct 21

Our founders @r_zarcone + @khosra will be on MTS later today to talk about our latest model Topos-2 and all things in AI biotech!

MTS @MTSlive Oct 21

PHP VULNERABILITY | DARIO LONGPOST | SI CONTROL STANDARDS x.com/i/broadcasts/1…
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ToposBio @ToposBio Sep 30

Today we are announcing Topos-2, our next-generation model for generating the full range of shapes a protein can take, across the order-disorder spectrum.

We are also previewing Topos-Bind: to our knowledge, the first generative model to capture the range of shapes for disordered proteins bound to small molecules.

Read the technical blog post here: toposbio.ai/topos-2-topos-…

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ToposBio @ToposBio Jan 8

Announcing Topos-1, an all-atom generative model that sets a new benchmark for predicting structural ensembles of intrinsically disordered proteins. Topos-1 outperforms existing models by a large margin, with implications for designing drugs for challenging targets ranging from cancer to neurodegenerative disease.

Read the full technical report on our website: toposbio.ai/tech-report