Amir Khosrowshahi

@khosra

Co-founder & CTO, Topos Bio

San Francisco, CA Joined May 2009

105 Following 1.4K Followers 88 Posts

Latest posts 5

Thanks @deantak and @Gina_YJ for the conversation .

We discussed why protein dynamics matter for drug discovery, and how we’re combining experimental data, simulations, and AI to tackle challenging targets.

ToposBio Verified account @ToposBio Oct 23

Understanding protein dynamics can open new paths to treating difficult diseases.

We spoke with GamesBeat about Topos-2, Topos-Bind, and our approach to designing drugs for dynamic proteins.

Thanks @deantak for the conversation!

gamesbeat.com/topos-bio-is-u…
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Amir Khosrowshahi @khosra Oct 23

Thank you @MTSlive for having us.

ToposBio Verified account @ToposBio Oct 23

Missed us on MTS? Here’s a clip from our conversation about modeling dynamic proteins and designing drugs for challenging disease targets.

Thanks @MTSlive for having us!
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Amir Khosrowshahi @khosra Jan 8

A small but meaningful step forward on the path towards treating diseases like Alzheimer's and cancer.

ToposBio Verified account @ToposBio Jan 8

Announcing Topos-1, an all-atom generative model that sets a new benchmark for predicting structural ensembles of intrinsically disordered proteins. Topos-1 outperforms existing models by a large margin, with implications for designing drugs for challenging targets ranging from cancer to neurodegenerative disease.

Read the full technical report on our website: toposbio.ai/tech-report

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Amir Khosrowshahi @khosra Jan 24, 2023

Funny clip of my instructor for Phys 253 and undergrad advisor.

Leo C. Stein is @duetosymmetry on bsky/threads/🐘 @duetosymmetry Jan 23, 2023

One of Sidney Coleman's most iconic quotes. Casually lighting up in lecture. Chugging coffee. The cheeky grin and laughing at his own jokes. This lecture had it all! (Will transcribe what he says below)
1/4

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Amir Khosrowshahi @khosra Sep 20, 2022

A wonderful thought provoking conversation with pioneering neuroscientist Jeff Lichtman on connectomics and many other topics.

Intel AI Verified account @IntelAI Sep 20, 2022

Listen in on a new episode of Intel on AI with @khosra and Prof. Jeff Lichtman from @harvardbrainsci. Together they’ll discuss researching the physical structure of the brain and its significant contributions to science. intel.ly/3RDuWUY

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