@VorobyovUCD
elifesciences.org Harnessing AlphaFold to reveal hERG channel conformational state secrets Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening... 
www.pnas.org Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2... Small-conductance Ca2+-activated K+ channels (SK, KCa2) are gated solely by intracellular microdomain Ca2+. The channel has emerged as a therapeuti... Press release for my latest paper. It was a very difficult 5 years of late nights and staring at data points but I think it will make a big impact for treatment of heart failure. Check it out if you're interested.View quoted post on X
phoenixmed.arizona.edu/newsroom/news/…
