Incredible work from Philip, @AA_Lab_EPFL, Rogier Sanders (@amsterdamumc) and more! Officially out in @cellhostmicrobe. We describe the presentation of Lassa GPC on nanoparticles and show it can induce neutralizing responses at a novel epitope. Full story: cell.com/cell-host-micr…
The Ward Lab
@WardLab1
A structural bio lab using electron microscopes to study HIV, Ebola, Flu, Malaria, Coronaviruses, and membrane proteins. Views are our own.
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Latest posts 5
Another malaria CSP antibody story describing the structural basis of how unique homotypic interactions in the L9 antibody result in a potent and protective phenotype! #malaria #cryoEM. Now available in BioRxiv biorxiv.org/content/10.110…
Great talk from Julianne and work from Team Flu!
Beautiful analysis of maturation and cross-reactivity of antibody responses following flu vaccination by @julianna_han @OptionsXi @WardLab1 Specificity lost to cross-reactivity and mapping of how HA escapes. Bonus points for having to work with @TheBcellArtist (my sympathies)View quoted post on X
Outstanding work from @HaileePerrett and Philip Brouwer, go check out the paper and the beautiful Lassa GPC figures. Congrats to all involved!
Really excited to finally share our work on #Lassa's fusion glycoprotein (GPC) on bioRxiv!View quoted post on X
We explore GPC structures across lineages, antibodies targeting the apex of the trimer (which impede receptor binding), and describe a new NAb!
Read more here!🔬
biorxiv.org/content/10.110…
Beautiful work done by our Post Doc Gregory Martin and team including Jon Torres, Grace Gibson, Wilma Lee, Jeffrey Copps. 😍 #thatcryotho #malaria #cryoEM
Very cool #cryoEM reconstructions from @WardLab1! These #malaria Fabs are so cute ☺️View quoted post on X
“Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection” | #bioRxiv biorxiv.org/content/10.110…