Jeannie Lee

@XistHarvard

X chromosome inactivation, imprinting, non-coding RNA, repetitive elements, epigenetics, 3D genome 🧬; neurodevelopmental disorders and therapeutics

Boston, Massachusetts x-inactivation-lee-lab.org Joined June 2018

212 Following 1.9K Followers 424 Posts

Latest posts 5

Jeannie Lee @XistHarvard Jul 24, 2025

An evolving landscape of PRC2–RNA interactions in chromatin regulation, by Aguilar @ragmau, Rosenberg, et al. now in print!

Learn the latest about how Polycomb works with RNA in epigenetic regulation:

nature.com/articles/s4158…

www.nature.com An evolving landscape of PRC2–RNA interactions in chromatin regulation Nature Reviews Molecular Cell Biology - This Perspective discusses unresolved questions about how the chromatin modifier Polycomb repressive complex 2 (PRC2) binds RNA in vivo and the functional...

Jeannie Lee @XistHarvard Jul 21, 2025

Jpx flips a bistable switch and reprograms the X-inactivation center in 3D by regulating CTCF loop formation.

sciencedirect.com/science/articl…

Congrats to Hyun Jung Oh, with team members Priyojit Das, Roy Blum, Andrea Kriz, Hun-goo Lee, and Yong-woo Lee!

Jeannie Lee @XistHarvard Mar 1, 2025

Our revised manuscript explains how Guo et al. concluded PRC2 is not an RNA binding protein. They retained unmappable reads, selectively removed read duplicates from the mappable fraction, and applied an arbitrary cutoff for PRC2 enrichment in RNA.
biorxiv.org/content/10.110…

www.biorxiv.org Re-analysis of CLAP data affirms PRC2 as an RNA binding protein Using CLAP methodology, Guo et al. recently concluded that PRC2 is not an RNA binding protein (RBP). They suggest that prior findings were CLIP artifacts and argue against RNA’s direct role in PRC2...

Jeannie Lee @XistHarvard Feb 19, 2025

A surprising discovery by @bujisic_bojan et al: The RNA component (7SL) of SRP regulates a global response to stress — controlling both transcription and translation. 7SL RNA is not just for ER translocation! Read about the findings here:

rdcu.be/d9S1q

Jeannie Lee @XistHarvard Jan 16, 2025

A biophysical basis for the spreading behavior and limited diffusion of Xist.
authors.elsevier.com/a/1kS2a_278y%7…
Xist and HNRNPK form a liquid droplet that encapsulates the X-chromosome and entraps other X-inactivation factors. Xist and HNRNPK pull on each other to enhance cis-spreading!