Yue YOU

@YueYOU9

Postdoc@Guangzhou LAB, Single cell analysis, Virtual cell modeling, AI Agent

Joined September 2019

362 Following 213 Followers 133 Posts

Latest posts 5

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Yue YOU @YueYOU9 Sep 15, 2022

Please check this out if you use pseudobulk scRNAseq samples for DE analysis! We are pleased to share this preprint with you with 2 new methods to deal with unequal group variances on pseudobulk data.

bioRxiv @biorxivpreprint Sep 14, 2022

Modelling group heteroscedasticity in single-cellRNA-seq pseudo-bulk data biorxiv.org/cgi/content/sh… #bioRxiv
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Yue YOU @YueYOU9 Apr 27, 2024

Inspired by the STD technique used by humans to solve for complex problems

bioRxiv Bioinfo @biorxiv_bioinfo Jan 20, 2024

Toward subtask decomposition-based learning and benchmarking for genetic perturbation outcome prediction and beyond biorxiv.org/cgi/content/sh… #biorxiv_bioinfo
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Yue YOU @YueYOU9 Apr 27, 2024

scELMO works from the side of gene embeddings generated by LLM. But based on GEARS, curious about which strategy provides better results.

Moritz Schäfer @muronglizi Apr 10, 2024

openreview.net/forum?id=eb3nd…

- A common problem in ML is to generalize to cases unseen during training

- Here, GPT- and protein embeddings enable perturbation effect prediction for unseen genes

- My take: Great direction and I anticipate more embedding 'arithmetics'
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Yue YOU @YueYOU9 Nov 15, 2023

Nice summary of available sc foundation models.💡

Will Connell @wilstc Jun 14, 2023

🧬🔮 Single cell foundation models have been a recent hot topic in bio-ML! A few of the recent methods and some thoughts 🧬🔮

1) Geneformer
2) scGPT
3) scFoundation
4) Exceiver
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Yue YOU @YueYOU9 Jan 31, 2023

We used scRNA-seq to study the germination of Arabidopsis embryos, and we found interesting transcriptional states of cells during that process. Happy collaboration with @LimCheeLiew, @lewseylab, and @QGouil! Come and read about that if you want to know more!

lewsey lab @lewseylab Jan 23, 2023

Latest from the lab. We found that cells of germinating Arabidopsis embryos pass through a common transcriptional state before they establish cell-type specific transcriptional identity, using single cell RNA-seq. Driven by @LimCheeLiew @QGouil @YueYOU9 biorxiv.org/content/10.110…
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