Xiaolan Zhao Lab

@ZhaoLab_SKI

We study chromosomal replication & recombinational repair mechanisms, Smc5/6, SUMO-based controls using multidisciplinary approaches. Tweets are a group effort.

1275 York Ave, New York City mskcc.org/research/lab/x… Joined July 2019

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Xiaolan Zhao Lab @ZhaoLab_SKI Nov 8, 2021

Please RT. Postdoc positions available in the Zhao Lab at Sloan Kettering Cancer Institute to study DNA replication, recombinational repair, SUMO, & Smc5/6. Be part of our fantastic group & live in the phenomenal NYC! More info below. Contact me at zhaox1@mskcc.org if interested.

Xiaolan Zhao Lab @ZhaoLab_SKI Sep 17, 2024

Congrats to all postdocs who submitted amazing photos. A special shot out for our very own Cory @chaluska18. His winning picture shows a beautiful view that we are lucky to see in our cool neighborhood!

MSK ScienceEducation @MSKEducation Sep 16, 2024

While our judges are deliberating who will take the top 3 places in the Postdoc Slam competition, let's congratulate our #NPAW2024 @MSKPDA 📸 contest winners!
🥇Cory Haluska from the @ZhaoLab_SKI
🥈FUN Dinesh Kumar from the Rosen Lab
🥉@kelsalohop from the @TabarViviane Lab

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Xiaolan Zhao Lab @ZhaoLab_SKI Jul 27, 2024

👇 This is just out in Genes Dev (DOI: 10.1101/gad.351667.124). Worthwhile to note that the human telomere SUMO-Repair team resembles those in yeasts; checkout a recent review by Gasser and Stutz discussing SUMO-Repair and their roles in telomeres (DOI: 10.1002/1873-3468.14751).

Xiaolan Zhao Lab @ZhaoLab_SKI Mar 2, 2024

SUMO powers "repair gathering" in the nucleus to get ALT going when PML goes missing 🍻. Congrats to @lab_zhang @rongweiz 👏, Glad to help 🙂
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Xiaolan Zhao Lab @ZhaoLab_SKI Jun 18, 2024

🔥🔥Excited to share a new publication at NSMB describing Smc5/6 structures in 3 states throughout the entire length of the complexes and functional studies. Great to work with Lanfeng Wang's lab, and congrats to all authors, including our own #chaluska1. tinyurl.com/yha2nu5x

Xiaolan Zhao Lab @ZhaoLab_SKI Mar 30, 2024

👇 Our new work on how cells regulate checkpoint recovery. Many studies have shown how cells turn on the DNA damage checkpoint, but less is known about how cells turn off it to reverse the stress response. Check out the preprint for new insights. 1/ biorxiv.org/content/10.110…

www.biorxiv.org Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes, such as cell cycle arrest, to cope with genome stress. After prolonged genotoxin treatment,...