Like every time, I had fun reading this foundational phase separation paper from the Rosen lab
New Online! A demonstration that multivalent interactions drive condensate formation dlvr.it/TTW5CgView quoted post on X
Huaiying Zhang
@lab_zhang
Assistant professor at Carnegie Mellon University, studies how phase transition organizes biochemistry in normal and cancer cells
414 Following 613 Followers 250 Posts
Latest posts 5
Happy to see this coming out at JCB!
Rongwei Zhao et al. @lab_zhang @CarnegieMellon show that, in #cancer cells using the alternative lengthening of telomeres (ALT) pathway, #SUMO levels at #telomeres influence the formation of ALT-associated PML bodies. hubs.la/Q03GK3qh0View quoted post on X
Thanks for highlighting our work ☺️
In this study, @rongweiz et al. report that SUMOylation, along with DNA repair factors and BLM helicase, promotes telomeric DNA synthesis and alternative lengthening of telomeres. @lab_zhang
Learn more here:
➡️ tinyurl.com/gd351667View quoted post on X
Check out our new paper. Very proud of you @rongweiz !
I am excited to share my work published on Genes & Development! Our study reveals a novel role of SUMOylation in ALT (Alternative Lengthening of Telomeres) pathway.View quoted post on X
genesdev.cshlp.org/content/38/13-…
Happy to share this preprint, in collaboration with @ShilaBanerji and @DMChenowethLab, driven by @DebSBanerjee1 and Tafazwa, where we find high surface tension droplets 💧 can undergo Ostwald ripening in the chromatin while low surface tension droplets cannot.
Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening biorxiv.org/cgi/content/sh… #biorxiv_biophysView quoted post on X
