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Joseph Watson

@_JosephWatson

Co-Founder @ Xaira Therapeutics
Former Baker Lab PostDoc at @UWproteindesign.
Interested in generative modelling for molecular design.
Views my own.
Joined September 2020
95 Following 3.1K Followers 133 Posts

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Joseph Watson @_JosephWatson
When we started @Xaira_Thera we were clear that for molecular AI to make a difference for patients, it had to be able to address the hardest and most clinically relevant problems; those that traditional methods haven't been able to solve.

For that, we've been building X-Design, bringing together top-tier research, engineering and wet lab capabilities into a model focused on designing clinically progressible molecules.

Today, we showcase just some of that work; designing functional, progressible antibodies for our "undruggable" XA-4 program de novo.

bit.ly/4hAOhEW
www.xaira.com De Novo Design of Progressable Antibodies to Therapeutic Targets | Xaira Therapeutics De Novo Design of Progressable Antibodies to Therapeutic Targets. News and insights from Xaira Therapeutics on AI-driven drug discovery and development.
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Joseph Watson @_JosephWatson
All the big things happening to all the best Davids!
Congratulations David 😍
David Juergens Verified account @DaveJuergens Oct 10, 2024
⚛️ I got a new job ⚛️

After 5 wonderful years at @UWproteindesign and @UWMolES, I’m headed to Palo Alto for a postdoc at @StanfordUChem under Todd Martinez.

SUPER excited to dive into deep learning for quantum chemistry and explore the Bay Area!!
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Joseph Watson @_JosephWatson
Congratulations to all - incredibly deserved! It was a total and constant honour working with David. His passion for protein design and its applications, as well as his uncanny attention to detail continue to inspire me. And nothing we do today would be possible without AlphaFold
The Nobel Prize Verified account @NobelPrize Oct 9, 2024
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Joseph Watson @_JosephWatson
Very exciting to see this work out! It still feels quite amazing that you can take three functional bits of protein and bring them all together with novel scaffolds, all while retaining their native function. Congratulations to @karla_mcastro for leading this super cool project!
protein design is getting weird ... and increasingly functional ! These are very weird designs !
biorxiv.org/content/10.110…
fun collaboration with @karla_mcastro @_JosephWatson @jueseph @UWproteindesign
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