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Arpaia Lab

@arpaialab

Mucosal Immunity | Cancer Immunology
Department of Microbiology & Immunology @Columbia_MI
Columbia University Irving Medical Center @ColumbiaMed
New York, New York arpaialab.nyc Joined June 2022
135 Following 242 Followers 35 Posts

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Arpaia Lab @arpaialab
Congrats Noah Chen and team! New paper out today in @NatureCancer: we ran a genome-wide screen in E. coli to find how bacteria thrive inside tumors, then built Ec-TA, a tumor-avid strain with better colonization and anti-tumor efficacy. Open access: nature.com/articles/s4301…
www.nature.com A genome‑wide screen in E. coli reveals metabolic adaptations that enhance intratumoral fitness and... Nature Cancer - Chen et al. conducted a genome-wide screen in E. coli to identify genetic determinants of intratumoral bacterial fitness and targets for therapeutic application.
Arpaia Lab @arpaialab
New paper from our lab, out today in @ScienceTM ! 🎉 Zaofeng Yang & team engineer a probiotic platform combining enzyme/prodrug chemo (CD/5-FC → 5-FU) with IL-15 + PD-L1 blockade, driving durable antitumor immunity! Free access: tinyurl.com/2k8c8axu
www.science.org Engineered probiotics for tumor-targeted combination chemoimmunotherapy A precision-engineered bacterial platform integrates enzyme/prodrug chemotherapy and immunotherapy to drive synergistic antitumor responses.
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Arpaia Lab @arpaialab
Great feature by @liamjdrew @Nature on bacteria-based cancer therapies! 🧫 IL-2 Salmonella (Saltzman), tetanus-recall Listeria (Gravekamp), self-destructing bacteria (@forbeslabumass), programmable circuits (@tdanino) – our work's part of this too! 🦠 youtu.be/lYuGzWGusuU
www.youtube.com A new way to target cancer People taking medication often experience side effects.This is part...