A great thread from @uthsavc describing some of the math behind GASTON, our new method for modeling spatial variation in gene expression, now out in @naturemethods!
GASTON, our method to learn “topographic maps” of gene expression, is out now @naturemethods!View quoted post on X
IMO the coolest part is a new model of *spatial gradients in sparse data*.
As is typical for bio papers, it’s buried in Methods, but see below for a quick outline on the math 👇
